Introduction: Alzheimer's disease (AD) is the most common cause of dementia in individuals over 60
years. It is characterized by the presence in the brain of extracellular senile plaques. This change
provides progressive neuronal degeneration and dysfunction, resulting in severe brain atrophy and
cognitive deficits. The neurodegeneration occurs in the dentate gyrus and CA1 subregion of the
hippocampus, entorhinal cortex and association neocortex. Through the discovery that constitutive
neurogenesis persists in the adult mammalian brain, including brain regions affected by AD, the
hypothesis that the disease could be overcome or ameliorated is born. The adult neurogenesis process
involves the proliferation of resident stem cells and neural progenitor cells and their migration,
differentiation into mature neurons and functional integration into the neural network. There are two
areas of the brain of adult mammals (rodents, monkeys and humans) in which neurogenesis occurs:
subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral
ventricles. Objective: This study aims at the treatment of AD from neural, mesenchymal stem derived
from adipose tissue stem cells and induced pluripotent stem cells. Materials and Methods: Systematic
review of current scientific literature from the PubMed and Scielo database. Discussion and Conclusion:
The stem cells include embryonic stem cells (ESC), induced pluripotent stem cells (iPSCs), stem cells
derived from tissue such as bone marrow (BM), and stem cells derived from adipose tissue. Stem cells
derived from neuron have the potential to integrate neural networks of the brain. The cell
transplantation appear to increase levels of acetylcholine to improve memory and cognition in animal
model. In addition, the stem cells secrete neurotrophic factors to modulate neuroplasticity and
neurogenesis. Adipose-derived stem cells (ADSCs) were induced to differentiate into astrocytes or
neurons and their transplant was successful, causing enhancement of neuronal function. Another study
which were also transplanted ADSCs in the hippocampus of transgenic mice for AD, it was concluded
that the transplantation of mesenchymal stem cells could stimulate neurogenesis in the brain of adult
rodents, as these cells secrete growth factors enhancing cell proliferation in the subgranular zone of the
dentate gyrus. This facilitates the differentiation of new cells in the subventricular zone, causing to
facilitate functional recovery in mice by neurogenesis. When ADSCs were administered intravenously in
mice models, such cells were found in the brain within twelve days after injection. A new study made
use of isolated human cells of patients with AD. These cells were then used to model the disease
offering an insight into its abnormal function compared with non-diseased cells and also how they may
be vulnerable to environmental factors. The stem cell therapy not only has the potential to replace
damaged neurons but also has the capacity to generate new astrocytes. Studies confirm that treatment
with stem cells can be effective and safe, especially through the advancement of new research.


Kumar,V; Abbas, A. K; Fausto, N. Robbins & Cotran:Patologia -Bases Patológicas das Doenças. 8ª

Ed. Rio de Janeiro: Elsevier,. 2010;

Li M, Guo K, Ikehara S. Stem Cell Treatment for Alzherimer`s Disease. Int. J. Mol. Sci. 2014,

(10), 19226-19238;

Ha S, Ahn S, Joo Y, Kim S, Joo Y, Chong YH, Suh YH, Chang KA. In vivo imaging of human adiposederived stem cells in Alzheimer's disease animal model. J Biomed Opt. 2014 May;19(5):051206.

doi: 10.1117/1.JBO.19.5.051206;

Muotri AR. Células-tronco pluripotentes e doenças neurológicas. Estud. av. vol.24 no.70 São

Paulo 2010;

Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ..Human stem/progenitor cells

from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus

of mice. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18171-6. Epub 2005 Dec 5;

Kan I, Barhum Y, Melamed E, Offen D. Mesenchymal stem cells stimulate endogenous

neurogenesis in the subventricular zone of adult mice. Stem Cell Rev. 2011 Jun;7(2):404-12. doi:


Yan Y, Ma T, Gong K, Ao Q, Zhang X, Gong Y. Adipose-derived esenchymal stem cell

transtontation promotes adult neurogenesis in the brains of Alzheimer’s disease mice. Neural

Regen Res. 2014 Apr 15; 9(8): 798–805;

Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk

M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ,

Coleman PD, van den Hove DL, Rutten BP. Epigenetic regulation of adult neural stem cells:

implications for Alzheimer’s disease. Mol Neurodegener. 2014 Jun 25;9:25. doi: 10.1186/1750-


Schaeffer EL. Enriquecimento ambiental como estratégia para promover a neurogênese na

doença de Alzheimer: possível participação da fosfolipase A2. Rev. psiquiatr. clín. vol.37 no.2

São Paulo 2010.